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1 article(s) from Konno, Sho

Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells

Fumihiro Ishikawa,
Sho Konno,
Hideaki Kakeya and
Genzoh Tanabe

Beilstein J. Org. Chem. 2024, 20, 445–451, doi:10.3762/bjoc.20.39

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Figure 1: Biosynthesis of gramicidin S. Modules comprise the PCP, A, E, C, and TE domains. PCP, peptidyl carr...

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Figure 2: (A) Adenylation reaction in a nonribosomal peptide synthetase. (B) Structures of aminoacyl-AMS inhi...

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Figure 3: Illustration of the inhibition of A-domains by aminoacyl-AMS derivatives in live bacterial cells. C...

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Scheme 1: Synthesis of 2′-OH-substituted ʟ-Phe-AMS derivatives. Reagents and conditions: (a) NaH, TBAI, R–X (...

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Figure 4: Competitive labeling experiments of GrsA using probe 3 in the presence of ʟ-Phe-AMS inhibitors. (A)...

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Published 26 Feb 2024

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